Project GYM: Physical Fitness Improves Wellbeing in Young Men With Hemophilia

A hemophilia-particular exercise instruction application, termed Task Health club, was proven to improve psychological wellbeing and self-confidence in younger adult men with hemophilia aged 18 to 25 several years.1,2

“Many younger adult men with hemophilia engage in physical action and activity, but facial area troubles to participation mainly because of their [condition],” wrote Paul McLaughlin, MSc, of the Katharine Dormandy Haemophilia Centre and Thrombosis Unit at the Royal Absolutely free London NHS Basis Have confidence in in London, United kingdom, and his coauthors.1

The scientists printed the success of 2 scientific studies on the safety and feasibility of Project Gymnasium in Exploration and Follow in Thrombosis and Haemostasis.1,2

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Nonblinded, Randomized Feasibility Examine

A nonblinded, randomized study was performed to consider the feasibility of Challenge Health and fitness center, and its influence on health club activity, determination, and adherence to training. The researchers provided 19 young adult men with hemophilia A or B (all severities, with or devoid of inhibitor) from 3 hemophilia facilities in London.

All research contributors had been presented an activity tracker and gymnasium membership, and ended up randomized to “gym only” or “gym and own trainer” groups. Questionnaires were administered at baseline and 6-months to evaluate participants’ commitment to exercise, actual physical activity levels, good quality of existence, self-efficacy, and self-esteem.

After investigation, the scientists discovered that contributors within just the “gym and personal trainer” group experienced increased gym attendance in comparison with the “gym-only” team. Particularly, 7 contributors elevated their action levels, even though 9 remained the identical, with no statistical difference among the groups.

The median Hemophilia Joint Health Scores (HJHS) enhanced in 3 members, but were being unchanged in 12. Moreover, there was no bleeding similar to health club exercise.

Observational Feasibility Examine

Kate Khair MSc, PhD, of the identical establishment as Mr McLaughlin, led a individual observational examine in the similar cohort as the randomized research. She and her workforce utilized thematic assessment to review person audio-recorded interviews about examine participation.

Right after analysis, they uncovered that there was a important distinction in enthusiasm to workout as proven by the Phases of Adjust grouping shifting from contemplation to action and upkeep phases (P =.03). In addition, self-efficacy all round scores trended to enhancement, but had been not statistically important (P <.06).

Furthermore, the median self-esteem scores of participants improved from 22 (range 12-30) to 25 (range 13-30), and were significant (P =.02).

“Key themes identified from the interviews were: fear, self-confidence, “being normal,” pain, weight loss, ability, and getting fitter,” Dr. Khair and coauthors wrote.

“The psychological wellbeing of young men with hemophilia improved during this study, [which] may have been related to participating in a gym-based, physical exercise program,” they added.

Future Directions

Importantly, this was the first study to evaluate a nonmedical gym environment and personal trainer-led physical fitness program in people with hemophilia. Overall, the results from both studies showed that training with personal trainers led to greater gym attendance and participants felt more supported compared with “gym-only” intervention.

“[We] highlight the need to [better] understand support needs in future studies,” the researchers concluded. “Behavior change theory and techniques should be included when investigating gym-based activity for young men with hemophilia.”

“In the future, we would love to replicate this study, particularly in women, and we are currently seeking additional funding to continue the project,” Dr. Khair said in an email interview.

Disclosure: Some guideline authors have declared affiliations with or received funding from the pharmaceutical industry. Please refer to the original study for a full list of disclosures.


  1. McLaughlin P, Holland M, Dodgson S, Khair K. Project GYM: a randomized feasibility study investigating effect on motivation of personal trainer-led exercise in young men with hemophilia. Res Pract Thromb Haemost. 20215(8):e12613. doi: 10.1002/rth2.12613
  2. Khair K, Holland M, Dodgson S, McLaughlin P, Fletcher S, Christie D. Fitness enhances psychosocial well-being and self-confidence in young men with hemophilia: results from Project GYM. Res Pract Thromb Haemost. 20215(8):e12622. doi: 10.1002/rth2.12622